The more stable, the more able.*

// Deposition of amyloid fibrils

The underlying cause of ATTR-CM

Transthyretin (TTR) is a tetrameric protein highly conserved through vertebrate evolution and involved in various physiological functions, including:

• Transport of thyroid hormone and retinol (vitamin A)
• Providing neuroprotection
• Supporting cognitive performance and memory
   

However, when the stability of TTR is compromised, misfolded TTR monomers can aggregate and form amyloid fibrils, which deposit in various organs. When amyloid fibrils deposit in the heart walls, symptoms like shortness of breath, fatigue, and dizziness can occur. Eventually, these deposits can lead to transthyretin amyloid cardiomyopathy
(ATTR-CM).